Altered motor axonal excitability in patients with cervical spondylotic amyotrophy |
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| Authors: | Chaojun Zheng Yu Zhu Cong Nie Feizhou Lu Dongqing Zhu Robert Weber Jianyuan Jiang |
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| Affiliation: | 1. Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China;2. Department of Physical Medicine and Rehabilitation, Upstate Medical University, State University of New York at Syracuse, Syracuse, NY 10212, USA;3. Department of Orthopedics, The Fifth People''s Hospital, Fudan University, Shanghai 200240, China;4. Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China |
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| Abstract: | ObjectiveTo investigate the changes in motor axonal excitability properties in cervical spondylotic amyotrophy (CSA).MethodsThreshold tracking was used to measure the median motor axons in 21 patients with CSA, 10 patients with cervical spondylotic radiculopathy (CSR) and 16 normal controls.ResultsCompared with normal controls, patients with distal-type CSA showed increased threshold electrotonus hyperpolarization (TEh [90–100]) and increased superexcitability on the symptomatic side (P?P?+ conductance may be less active in motor axons in patients with CSA.ConclusionsThe present study demonstrated changes in motor axonal excitability in patients with CSA compared with both normal controls and patients with CSR.SignificanceLess expression of slow K+ conductance may confer greater instability in membrane potential in CSA, thereby presumably contributing to the increased vulnerability of motor axons in patients with CSA. |
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| Keywords: | Threshold tracking Cervical spondylotic amyotrophy Motor axonal excitability |
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