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A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers
Authors:Jonasdottir Aslaug  Thorlacius Theodora  Fossdal Ragnheidur  Jonasdottir Adalbjorg  Benediktsson Kjartan  Benedikz John  Jonsson Hjortur H  Sainz Jesus  Einarsdottir Helga  Sigurdardottir Sonja  Kristjansdottir Gudlaug  Sawcer Stephen  Compston Alastair  Stefansson Kari  Gulcher Jeffrey
Affiliation:deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland. aslaug.jonasdottir@decode.is
Abstract:Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) with a complex genetic background. Here we use a genome-wide association strategy with 4804 microsatellite markers successfully typed in separately pooled DNA from 200 patients and 200 controls. A total of 91 markers showed evidence of association. When compared to our in-house physical map of the genome, six 2-Mb regions containing at least two of these markers were detected. Of those, three regions have one or more markers among the 20 most strongly associated: chromosomes 3q25, 6p21.3 (the MHC region) and 19q13.
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