滋补肝肾、活血祛痰方药对原发性高血压大鼠左心室肥厚的影响

目的：探讨滋补肝肾、活血祛痰方药早期干预对原发性高血压左室肥厚(EH—LVH)大鼠左室功能的影响。方法：在原发性高血压大鼠(SHR)孕期及子代出生后10周前给予滋补肝肾、活血祛痰方药治疗，观察该方药对其子鼠血压、左室肥厚的影响。结果：10周龄SHR即已形成一定程度的左室肥厚，经滋补肝肾、活血祛瘀方药早期干预，其子代大鼠血压显著下降(P＜0．05)，左室肥厚明显消退(P＜0．01），心室肌胶原蛋白浓度显著降低(P＜0．01)。结论：子代胚胎形成期及出生后10周前可能是SHR高血压发生、发展的重要时期，在此期经滋补肝肾、活血祛痰方药干预，能够减弱其发病，起积极预防作用。

Effect of Formula for Nourishing the Liver and Kidney and Promoting Blood Circulation to Remove Stasis on Left Ventricular Hypertrophy of Primary Hypertensive Rats

To study the effect of formula of nourishing the liver and kidney and promoting the blood circulation to remove stasis of left ventricular hypertrophy (LVH) of primary hypertensive rats (SHR).Method:SHR were treated with FNP during pregnancy and the offspring rats were treated before ten weeks old.The blood pressure and function of left ventricle were observed in the offspring rats.Result:LVH had already formed in the offspring rats only 10 weeks old.But after early treatment,their blood pressure decreased,LVH diminished,and the myocardium collagen in ventricle reduced significantly (P<0 05,0 01,0 01 respectively).Conclusion:Embryonic period and the period of ten weeks after born may be important to form hypertension in SHR.FNP has prophylactic function of protecting the rats from hypertension.