Immunity against hepatitis E virus infection: Implications for therapy and vaccine development |
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| Authors: | Mohamad S. Hakim Aqsa Ikram Jianhua Zhou Wenshi Wang Maikel P. Peppelenbosch Qiuwei Pan |
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| Affiliation: | 1. Department of Gastroenterology and Hepatology, Erasmus MC‐University Medical Center and Postgraduate School Molecular Medicine, Rotterdam, The Netherlands;2. Department of Microbiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia;3. Atta‐Ur‐Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan;4. State Key Laboratory of Veterinary Etiological Biology, National Foot‐and‐Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, PR China |
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| Abstract: | Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and patients have improved our understanding of HEV immunopathogenesis and informed the development of new antiviral therapies and effective vaccines. In this review, we discuss the recent progress on innate and adaptive immunity in HEV infection, and the implications for the devolopment of effective vaccines and immune‐based therapies. |
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| Keywords: | adaptive immunity hepatitis E virus innate immunity therapy vaccine |
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