Lymphoepithelioma-like carcinoma of the vulvar region

A case of lymphoepithelioma-like carcinoma of the vulvar region is described. Histologically, the tumour was similar to lymphoepithelioma of the nasopharynx but was Epstein-Barr virus negative. Infiltrating lymphocytes were predominantly T-cells, but also included some B-cells. Immunohistochemical stains showed positivity in tumour cells for cytokeratins but negativity for neuroendocrine markers, the melanoma-associated antigen, HMB45 and leucocyte common antigen. We conclude that the tumour histologically resembles lymphoepithelioma of the nasopharynx and lymphoepithelioma-like carcinomas of the skin, and has no relation to prior infection with the Epstein-Barr virus.