| 利奈唑胺在儿科应用研究进展 |
| |
| 引用本文： | 佟若菲,金玉洁.利奈唑胺在儿科应用研究进展[J].现代药物与临床,2013,28(1):66-68. |
| |
| 作者姓名： | 佟若菲 金玉洁 |
| |
| 作者单位： | 1. 天津市儿童医院,天津,300060
2. 天津药物研究院医药信息中心,天津,300193 |
| |
| 摘 要： | 利奈唑胺(linezolid)是第一个临床应用的新型(噁)唑烷酮类抗生素,通过抑制细菌蛋白质的合成达到抑菌的作用.因利奈唑胺独特的作用位点和方式,故不易与其他基于抑制蛋白合成发挥抗菌作用的药物发生交叉耐药,而本身也不易诱导产生耐药性,其临床疗效已经得到一系列Ⅲ期临床研究证明.现就其作用机制、儿科临床应用及不良反应进行综述.
|
| 关 键 词： | 利奈唑胺 (噁)唑烷酮 革兰阳性菌 临床应用 不良反应 |
Application of linezolid in pediatrics |
| |
| TONG Ruo-fei,JIN Yu-jie.Application of linezolid in pediatrics[J].Drugs & Clinic,2013,28(1):66-68. |
| |
| Authors: | TONG Ruo-fei JIN Yu-jie |
| |
| Institution: | 1.Tianjin Children’s Hospital,Tianjin 300060,China 2.Center for Drug Informatics,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China |
| |
| Abstract: | Linezolid is the first new antibiotics of oxazolidinone class in clinical application to play inhibitory effect by inhibiting bacterial protein synthesis. Linezolid has the unique site and way of action so it is not easy to produce cross-resistance with other antimicrobial that could inhibit protein synthesis and induce the resistance in vivo. Its clinical efficacy has been shown in a series of phase III clinical studies. This article reviews its mechanism of action, clinical applications, and adverse reactions in pediatrics. |
| |
| Keywords: | linezolid oxazolidinone gram-positive bacteria clinical application adverse reactions |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
| 点击此处可从《现代药物与临床》下载免费的PDF全文 |
|
