前列地尔脂微球载体制剂在生理盐水和葡萄糖注射液中的稳定性研究

目的 考察前列地尔脂微球载体制剂与生理盐水、5％葡萄糖注射液配伍的稳定性.方法 在室温25℃避光条件下,考察配伍液的pH值及外观的变化,采用高效液相色谱法测定前列地尔配伍液在0～4 h含量及有关物质的变化,并采用静态激光散射计测定配伍液的平均粒径、90％累积粒径的变化.结果 前列地尔脂微球载体制剂分别与生理盐水注射液、5％葡萄糖注射液配伍后4h内pH值、外观、含量、有关物质、平均粒径及90％累积粒径均未发生明显变化.结论 前列地尔脂微球载体制剂在室温避光条件下放置4h内稳定性较好,各项指标均符合国家标准,临床使用时可以依照病人情况选用静脉滴注的方式给药.

Stability of lipo prostagradin E1 in normal saline and glucose injection

Glycyrrhizic acid has significantly protective effects on hemorrhagic, ischemic, ischemic-reperfusion encephalic injury, ischemic-reperfusion spinal cord injury, and chemicals-induced neuron damage, and improves the performance of learning and memory of rats with ischemic dementia. In this paper, the advances in pharmacologic studies on glycyrrhizic acid, glycyrrhetinic acid, diammonium glycyrrhizinate, and carbenoxolone in the protection of encephalic injury and the improvement of memory are reviewed. It is suggested that the encephalic protection of glycyrrhizic acid is a comprehensive result of the basic actions with anti-inflammatory, anti-oxidative, anti-apoptosis, anti-cholinesterase, and moderate glucocorticoid-like effects.