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Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis |
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| Authors: | Oakley Fiona Meso Muriel Iredale John P Green Karen Marek Carylyn J Zhou Xiaoying May Michael J Millward-Sadler Harry Wright Matthew C Mann Derek A |
| Affiliation: | Liver Group, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, General Hospital, Southampton SO16 6YD, England, UK. |
| Abstract: | |
| Keywords: | HSC, hepatic stellate cells IκB, inhibitor of κB IKK, inhibitor of κB kinase IL, interleukin JNK, Jun N-terminal kinase MMP, matrix metalloproteinase MPT, mitochondrial permeability transition NBD, NEMO-binding domain NF-κB, nuclear factor-κB α-SMA, α-smooth muscle actin TIMP1, tissue inhibitor of metalloproteinase 1 TMRM, tetramethylrhodamine methylester TNF, tumor necrosis factor TUNEL, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling |
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