87例浸润性乳腺癌bc1-2和p53蛋白表达关系及其意义的探讨

为探讨bc1-2、p53在乳腺癌中表达的关系及意义。应用构缘酸—ABC—免疫组化法，对87例浸润性乳腺癌石蜡包理组织进行检测。结果：bc1－2＋／p53＋13例（14．94％），bc1－2—／P53—9例（10．34％），bc1－2＋／p53—42例（48．28％），bcl－2—／p53＋23例（26，44％），bcl－2和p53表达率之间呈明显负相关性（P＜0.01）。bcl－2—／p53十与bc1-2＋／p53—表达表型比较，分化差，核分裂多，淋巴结转移，复发，脏器转移，生存期＜5年，ER、PR阴性，PCNA强表达请参数中，差异均有显著性意义（P＜0．01），bc1-2＋／p53＋比bc1-2—／p53—表达表型分化差（P＜0．05）。提示：bc1－2和p53蛋白表达表型与浸润性乳腺癌的预后间存在着密切联系，以bc1－2＋／P53—为最佳，bc1－2—／P53＋为最差，另两种表型介于中间，但bc1-2—／P53—似较bc1－2＋／P53十为佳。bc1－2、p53蛋白表达和乳腺癌坏死之间无明显相关性。

The Relationship Between Expression of bc1-2 and p53 and Its Significance in Breast Cancer-A Study of 87 Cases

The relationship between expression of bc1-2 and p53 and its significance in breast cancer was in-vestigated- Authors detected the expression of bcl-2 and p53 in 87 formalin fixed paraffin embedded breast cancertissue by means of citric acid-ABC-microwave immunohistochemic staining. Results :Both bc1-2 and p53 were posi-tive in 13 cases (14. 94%), both were negative in 9 cases (10- 34%), bc1-2 positive but p53 negative in 42 cases(48.'28% ),bc1-2 negative but p53 positive in 23 cases (26. 44% ). There was a significant negative correlation be-tween the expression bcl-2 and that of p53(P<0.01). The phenotype of bc1-2 /p53-indicated the best prognosis while bcl-2- /p53- indicated the poorest prognosis. There was no significant corre1ation between necrosis ofbreast cancer and different kind of expression of the two genes. Conclusion: Combined detection of the expressionof bcl-2 and p53 may be helpful in estimating prognosis of breast cancer.