Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis |
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Authors: | Veronese Rodrigues Maria de Lourdes de Castro Figueiredo José Fernando Deghaide Neifi Hassan Saloum Romão Erasmo Vieira de Souza Nivaldo Donadi Eduardo Antonio |
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Affiliation: | Faculty of Medicine of Ribeir?o Preto, Ophthalmology 12 andar, Campus USP, University of S?o Paulo, 14048-900 Ribeir?o Preto, S?o Paulo, Brazil. mdlvrodr@fmrp.usp.br |
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Abstract: | PURPOSE: To evaluate the human leucocyte antigen (HLA) class 1 (HLA-A and HLA-B) and HLA class 2 (HLA-DRB1 and HLA-DQB1) allele profiles in the susceptibility to cytomegalovirus retinitis (CMV-R) in patients with AIDS. METHODS: Cytomegalovirus retinitis was clinically diagnosed by indirect binocular ophthalmoscopy. Human leucocyte antigens class 1 were typed using a complement-dependent microlymphocytotoxicity assay, and HLA class 2 alleles were identified using amplified DNA hybridized to sequence-specific oligonucleotide primers. RESULTS: The frequencies of HLA class 1 antigens and HLA class 2 alleles observed in patients and controls were similar; however, HLA-A31 antigen was over-represented in patients with AIDS, independent of the presence of CMV-R. CONCLUSION: There was no association between HLA molecules/alleles and CMV-R in Brazilian patients with AIDS. However, the results support the role of the HLA system in the susceptibility to developing AIDS. |
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