高同型半胱氨酸血症及其相关因素与青年脑梗死的关系

目的探讨同型半胱氨酸(homocysteine,Hcy)及其相关因素与青年脑梗死的关系。方法比较40例青年脑梗死患者(初发年龄<=45岁),30例神经系统非血管性疾病(NVD)患者和30例健康人血浆Hcy水平。分析年龄、性别、体重指数、肝肾功能、吸烟、嗜酒、血清VitBl2、叶酸水平的影响。结果脑梗死组血浆Hcy水平(21.4±18.8umol/L)分别与神经系统非血管疾病组(10.2±5.0umol/L)和健康对照组(12.9±8.6umol/L)比较差异均有显著性(P<0.01)。叶酸、VitB12与Hcy呈负相关,二者的降低与青年脑梗死关系密切(P<0.01)。血肌苷增高和吸烟与Hcy增高有关(P<0.05)。男性Hcy显著高于女性(P<0.05)。结论Hcy和青年脑梗死密切相关,与叶酸、VitBl2呈负相关,与肌苷呈正相关。男性、吸烟也与Hcy增高有关。

Hyperhomocysteine and Young Adults With lschemic Stroke

Objective: To investigate the relationships of plasma homocysteine (Hcy)levels and ischemic stroke in young Adults. Methods: The plasma homocysteine(Hcy)among forty cases with young adult ischemic cerebral disease(age at first event,<=45 years, CI group)were investigated,. Thirty age-and sex-matched healthy persons(Control group) and thirty persons with nervous system disease but vascular disease(NVD group) were used as controls.All the subjects underwent brain CT or MRI examination,serum vitaminB12 and folic acid examination,besides examination of plasma Hcy. The effects of age, sex, liver function, renal function, smoking,drinking, serum vitaminB12,and folic acid were analyzed. Results: The mean plasma Hcy was significantly higher in the CI group(21.4±18.8umol/L) compared with NVD group and control group(10.2±5.0umol/L and 12.9±8.6umol/L,P<0.01). Plasma Hcy level was inversely related to serum folate and vitamin B 12 concentrations whereas positively related to serum creatinine and smoking in all the three groups. The Hcy concentration of males was significantly higher than females in all groups. Conclusion: In this population , elevated plasma homocysteine is strongly associated with an increased prevalence of cerebral infarction in young adult, plasma Hcy level was inversely related to serum folate and vitamin B12 concentrations whereas positively related to serum creatinine and smoking.