早期干预对改善新生儿缺氧缺血性脑病患儿智力发育的研究

为评价早期干预对改善新生儿缺氧缺血性脑病（HIE）患儿智力发育的效果，以62例中、重度HIE患儿随机分为干预组30例和常规育儿组32例，另设同期正常新生儿30例为对照组。干预组从新生儿期开始接受为期24月－30月的以家庭为中心的干预治疗。所有病例均于生后每隔3月－6月进行智能发育检测。结果干预组1岁、2岁时智力发育指数（MDI）、运动发育指数（PDI）比常规育儿组高（P＜0．01），可达正常对照组水平（P＞0．05）；干预组康复率为93％，而常规育儿组仅为72％，提示早期干预可促进HIE患儿智力发育，有效地防治HIE所致的后遗症。

Early intervention for the enhancement for intellectual development of neonates with hypoxic ischemic encephalopathy

In order to evaluate the effect of early intervention on modifying the intellectual development of newborn infants with hypoxic ischemic encephalopathy(HIE),62 cases were collected to be randomly assigned to early intervention group(30 cases)and conventional care group(32 cases)as well as 30 healthy newborns as normal control.Just from the beginning of the birth,intellectual development assessment was tested every 3 to 6 months in neonates of all 3 groups during a time conrse of 24-36 months after birth. The results obtained showed that mental development index(MDI)and physical development index(PDI)in early intervention group was much higher than those in conventional care group(P<0.01)and caught up with the level of normal control group(P>0.05).Also,the recovery rate of early intervention group was as high as 93% in comparison with 72% in conventional care group.All these data indicate that early intervention could promote the intellectual development of newborn infants with HIE and,furthermore,it could be much beneficial in the prevention of sequelae caused by HIE.