冠心病危险因素单中心临床分析

目的:探讨冠心病(CHD)危险因素及其与冠脉病变的关系。方法:根据冠脉造影结果将患者分为CHD组(n=376)和非CHD组(n=110),回顾性分析临床资料。结果:(1)与非CHD组比较,CHD组的男性比例、吸烟率、年龄、糖尿病、谷丙转氨酶、直接胆红素、肌酐、尿素氮、尿酸及空腹血糖较高,而总胆红素、白蛋白、白球比值、高密度脂蛋白及载脂蛋白A-I较低;校正其他危险因素后,男性、高龄、吸烟、总胆红素、直接胆红素、肌酐、空腹血糖及载脂蛋白A-I仍与CHD相关。(2)载脂蛋白A-I与冠脉病变总积分显著相关;空腹血糖与冠脉病变支数及病变总积分的相关性均显著。结论:男性、高龄、吸烟、总胆红素、直接胆红素、肌酐、空腹血糖及载脂蛋白A-I为CHD的独立危险因素,其中空腹血糖和载脂蛋白A-I还与CHD的病变程度相关。

Clinical analysis of risk factors for coronary heart disease in one single center

Objective:To investigate the relationship between risk factors and coronary heart disease(CHD)as well as lesion severity.Methods:Retrospective analysis was carried out in 486 patients(376 patients wtih CHD and 110 patients without CHD)who had suspected coronary heart disease and received coronary angiography.Results:(1)Compared with non-CHD patients,CHD patients showed higher levels of proportion of men,smoking,age,diabetes,alanine amino transferase,direct bilirubin,serum creatinine,blood urea nitrogen,uric acid and fasting blood glucose and lower levels of total bilirubin,albumin,albumin/globulin,high-density lipoprotein and apolipoprotein A-1.After adjusted for other risk factors,men,older age,smoking,total bilirubin,direct bilirubin,creatinine,fasting blood glucose and apolipoprotein A-1 were still related to CHD.(2)Apolipoprotein A-1 was significantly related to Gensini’s score,while fasting blood glucose was associated not only with number of diseased coronary vessels but also with Gensini’s score.Conclusion:Men,older age,smoking,total bilirubin,direct bilirubin,creatinine,fasting blood glucose and apolipoprotein A-1 are independent correlative risk factors of CHD,meanwhile,fasting blood glucose and apolipoprotein A-1 also affect the severity of lesions in CHD.