雌激素对女性认知功能的影响

雌激素对中枢神经系统有许多有利作用,并且参与学习和记忆的脑功能调节。因此有研究推测绝经后雌激素水平的改变是女性认知相关疾病的高危因素。目前对围绝经期或绝经后女性的各项研究得出的矛盾性结果,推测出雌激素在阻止中老年妇女认知功能下降的治疗中存在一个关键的时期。根据这一假说,在人及动物研究中,通过分析与认知相关脑功能区域对雌激素改变的反应,以及补充外源性雌激素对脑功能的影响,来探讨女性雌激素对认知功能的影响以及雌激素治疗开始时间是否是防止或加剧认知功能障碍的重要因素。这对防治绝经后女性认知功能下降有重大意义。

Effects of Estrogen on Cognitive Function in Women

Estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory.Therefore,it has been hypothesized that the change of estrogen levels in women following menopause is associated with cognitive-related diseases.Now,contradictory results in the studies of menopausal or postmenopausal women have prompted speculation that a critical period exists for hormone treatment to protect against cognitive decline in older women.Consistent with this hypothesis,studies in both women and rodents discussed the effects of estrogen on cognitive function and whether the initiation of hormone treatment is an important factor of preventing or exacerbating cognitive impairment by analyzing the change of brain function when estrogen drops and exogenous estrogen is supplied,which is greatly significant for prevention and treatment of cognitive decline in women following menopause.