炎症因子CTRP1血清水平与冠心病的研究

目的:探讨补体C1q肿瘤坏死因子相关蛋白1(CTRP1)血清水平与稳定型心绞痛(SA)和急性冠脉综合征(ACS)的关系。方法:将1263例在我院接受冠状动脉造影的患者分为正常对照组(n=396)、SA组(n=451)和ACS组(n=416)。再将ACS组分为ST段抬高型心梗组(STEMI)和不稳定型心绞痛/非ST段抬高型心梗(UA/NSTEMI)组。采用酶联免疫吸附法(ELISA)检测血清CTRP1水平。结果:ACS组血清CTRP1水平明显高于其他两组,SA组血清CTRP1水平显著高于正常对照组。STEMI组血清CTRP1水平显著高于UA/NSTEMI组(P<0.01)。SA亚组分析显示,多支病变组血清CTRP1显著高于单支病变组。冠心病患者血清CTRP1水平与肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hsCRP)水平呈正相关。结论:CTRP1可能参与冠心病发病。

Increased serum CTRP1 levels are associated with the presence and severity of coronary artery disease

Objective:To analyze serum levels of C1q/TNF-related protein(CTRP)1 in patients with stable angina(SA)and acute coronary syndrome(ACS)for potential association of CTRP1 with these diseases.Methods:A total of 1263 participants were included in this study,categorized as control group(n=396),SA group(n=451)and ACS group(n=416).Serum levels of CTRP1 protein were analyzed using commercially available ELISA kits.Results:Serum CTRP1 levels were significantly elevated in patients with coronary artery disease(CAD),and were the highest in the ACS group(for all comparison,P<0.01).This bio-measurement was further analyzed by classifying ACS patients into STsegment elevation myocardial infarction(STEMI)and unstable angina/non-ST-segment elevation myocardial infarction(UA/NSTEMI)subgroups.As expected,STEMI patients had higher CTRP1 levels than UA/NSTEMI patients.Among the SA group,agreater serum level of CTRP1 was observed in patients with multi-vessel coronary artery disease.Moreover,CTRP1 was positively correlated with tumor necrosis factor(TNF)-αand high sensitivity C-reactive protein(hsCRP)levels.Conclusion: Serum CTRP1 levels are associated with the presence and severity of CAD,indicating that CTRP1 is involved in the pathophysiology of CAD.