糖代谢异常与子宫内膜癌关系的研究进展

机体糖、脂及蛋白质代谢异常导致的糖尿病、肥胖和高血压是子宫内膜癌发病的高危因素,代谢紊乱性疾病发生发展的各个环节与子宫内膜癌的发病机制密切相关,两者存在共同的激素水平异常及代谢酶类和细胞因子的表达异常。其中,糖代谢异常的可能致病基础胰岛素抵抗导致多种肿瘤的发生发展,其与子宫内膜癌发病的关系也日益受到重视。通过改善机体糖代谢状况,治疗糖尿病以及控制体质量等提高内膜癌治愈率,成为指导预防及治疗内膜癌的有效手段。

The Progress of Relationship Between Glucose Metabolic Disorder and Endometrial Carcinoma

Glucose metabolic disorder can cause Impaired fasting glucose(IFG) and Impaired glucose tolerance(IGT),even Diabetes Mellitus,Obesity and Hypertension.These diseases are caused by glucose,lipid and protein metabolic disorder,which are closely related with many kinds of carcinoma,such as rectal cancer,breast cancer and of couse endometrial cancer.Refering to the essential aspect,insulin resistance maybe the most important reason.In the future,we can increase the curative ratio of endometrial cancer through improving the glucose metabolic disturbance,controling body weight and treating Diabetes,all of which may turn into efficient measures of the prevention and treatment of Endometrial carcinoma.