3D MRI诊断胎儿体表畸形的研究

目的 研究3D MRI显示胎儿体表正常结构和畸形的临床应用价值.方法 对34例孕妇行US检查和MRI检查.胎儿尸检及出生后随访证实体表畸形36例,共42处.MR扫描均采集单次激发快速自旋回波序列(SSFSE),厚层重T2WI,三维稳态进动快速成像(3D FIESTA)序列,然后对3D FIESTA序列原始数据行多平面重...

3D MRI investigation on fetal surface malformations

Objective:To investigate the clinical value of three dimensional magnetic resonance imaging(3D MRI) in displaying the normal and abnormal structures of fetal surface malformations.Materials and Methods:Thirty-four pregnant women were examined by conventional prenatal ultrasonography(US) and MRI,36 fetus with surface malformations were conformed by follow-up results and autopsy.Single-shot fast spin-echo T2 weighted sequences(SSFSE) and thick-slab heavy T2WI with SSFSE were performed,3D MRI with three dimensional fast image employing steady-state acquisition(3D FIESTA) were acquired.Volume rendering(VR),muti-planar reconstruction(MPR) and MR virtual endoscopy(MRVE) were employed in image post-processing on workstation.The results from 2D MR,3D MRI and US images were compared with each other as well as the autopsy and follow-up results.Results:A total of 42 fetal surface malformations were identified by autopsy and follow-up after birth.3D MRI was not affected by the complex superficial curvature changes,and could clearly demonstrate the surface features,and spatial positions of the fetus.The sensitivity,specificity,accuracy of 3D MRI/2D MRI/3D US were 90.48%/69.05%/95.12%,100%/100%/99.81%,99.31%/97.74%/99.48%.There were obvious statistical difference for sensitivity and accuracy of 2D MRI and 3D MRI,and unobvious statistical difference for sensitivity,specificity,and accuracy of 3D MRI and 3D US.Conclusion:3D MRI is better than conventional 2D MRI in displaying fetal normal surface structure and malformations,and it has lager fov and higher soft tissue resolution than US.The 3D fetal MR imaging can be used as a complementary strategy to US in diagnosing fetal surface malformations.