血清CA19-9及CA125测定诊断子宫内膜异位症

目的:探讨血清CA19-9及CA125测定对子宫内膜异位症(EMs)的诊断价值。方法:采用放射免疫法测定55例EMs患者血清CA19-9及CA125水平,并与同期门诊健康妇女(对照组)进行比较。结果:EMs组及对照组血清CA19-9和CA125检测值的中位数及阳性率分别为27.81 U/mL、43.6%,11.78 U/mL、0和24.2 U/mL、36.3%,9.02 U/mL、4.0%。两组间差异均有统计学意义(均P<0.05)。中重度(Ⅲ～Ⅳ期)EMs患者与轻度(Ⅰ～Ⅱ期)患者血清CA19-9和CA125中位数和阳性率分别为42.38 U/mL、57.9%,17.36 U/mL、11.8%和34.75 U/mL、50.0%,15.3U/mL、5.9%,不同分期间差异有统计学意义(均P<0.05)。血清CA19-9和CA125诊断EMs的敏感度、特异度及准确度分别为43.6%、100%、61.25%及36.3%、96.0%、55.0%。结论:血清CA125和CA19-9在EMs患者中均有明显升高,测定两种血清标记物水平可协助EMs的诊断;两者血清水平与EMs患者病情程度有关。

The Clinlical Value of CA19-9 Verses CA125 in Diagnosis of Endometriosis

Objective:To investigate the diagnostic values of CA19-9 and CA125 in the serum for endometriosis.Methods:CA19-9 and CA125 serum levels were determined with RIA in 55 patients with endometriosis and 25 control healthy women.Results:the mean serum levels and positive rate of CA19-9 and CA125 for endometriosis and controls are 27.81 U/mL、43.6%,11.78 U/mL,0 and 24.2 U/mL、36.3%,9.02 U/mL,4.0%,respectively.There is significant difference between the measure result and positive rate of CA19-9 and CA125 for endometriosis group and control(P<0.05).The mean serum levels of CA19-9 and CA125 in patients at stages Ⅲ～Ⅳ and Ⅰ～Ⅱ,according to the Revised American Fertility Society(R-AFS) classification,are 42.38 U/mL、57.9%,17.36 U/mL、11.8% and 34.75 U/mL、50.0%,15.3 U/mL、5.9%.The difference of the mean serum levels and positive rate between the groups is significant(P<0.05).The sensitivity,specificity and accuracy of CA19-9 and CA125 serum levels in diagnosis of endometriosis are 43.6%,100% and 61.25%;36.3%,96.0% and 55.0%,respectively.Conclusions:Measure the levels of CA19-9 and CA125 in serum can raise the sensitivity of diagnosis for endometriosis.The predictive values of CA19-9 and CA125 seem high only to predict severe(stages Ⅲ and Ⅳ) disease.