表观扩散系数鉴别良恶性软组织肿瘤价值的Meta 分析

目的 探讨扩散加权成像中不同范围b值的平均ADC值鉴别良恶性软组织肿瘤的价值.材料与方法检索中外数据库,筛选出在不同b值下的平均ADC值及SD值.采用Medcalc软件对数据进行分析,计算SMD值及SMD(95% CI ).结果 纳入文献10篇.当b值≤400 s/mm2、500 s/mm2≤b值≤700 s/mm2、800 s/mm2≤b值≤1000 s/mm2时,良恶性软组织肿瘤的平均ADC值的SMD(95%CI )分别为0.86 (-0.46～2.19)、1.50 (0.79～2.21),0.93 (0.40～1.46).当b值≤400 s /mm2时,良恶性病变的平均ADC值的差异没有

A Meta analysis on apparent diffusion coefficient used to differentiate benign from malignant soft tissue tumors

Objective:To evaluate diagnostic value of mean apparent diffusion coefficient(ADC)values depending on b value ranges on differentiating benign from malignant soft tissue tumors in diffusion-weighted imaging.Methods:A comprehensive search was conducted to screen out mean ADC values and SD values from included studies.Meta-analysis was applied with Medcalc software for calculation of standardized mean differences(SMD) of mean ADC values and 95% confidence intervals(CI) for SMD.Results:Ten studies were included in this Meta-analysis.B value ranged from 0 to 400 s/mm2 with a SMD(95% CI) of 0.86(-0.46—2.19),500 to 700 s/mm2 with that of 1.50(0.79—2.21),and 800 to 1000 s/mm2 with that of 0.93(0.40—1.46).There was no statistically significant difference in mean ADC values between benign and malignant soft tissue tumors when b value ranged from 0 to 400 s/mm2,and there were statistically significant differences when b value ranged from 500 to 700 s/mm2 and 800 to 1000 s/mm2,but SMD of the former exceeded that of the latter.Conclusions:ADC values in diffusion-weighted MRI maybe have more potential value in differentiating benign soft-tissue tumors from malignant ones when b value ranged from 500 to 700 s/mm2.