孤立性轻度侧脑室增宽胎儿的产前诊断及预后

目的：探讨孤立性轻度侧脑室增宽胎儿的产前诊断结果及临床预后，为临床咨询提供指导。方法：对61例超声诊断为孤立性轻度侧脑室增宽的胎儿，回顾性分析其产前诊断结果；随访其生后情况。结果：①61例产前诊断中，3例（4.92%）染色体核型异常，包括2例21-三体综合征和1例47，XXY；50例行脐血弓形虫、巨细胞病毒及风疹病毒-IgM检测，仅1例脐血风疹病毒-IgM阳性。定期随访的55例中，8例因各种因素终止妊娠，包括3例染色体核型异常和1例脐血风疹病毒-IgM阳性；47例活产儿中，1例生后发现多发畸形，1例新生儿期死亡，2例伴有生长发育障碍，43例（91.49%）生长发育正常。结论：对孤立性轻度侧脑室增宽胎儿，建议行产前诊断及感染项目检测，排除染色体异常和先天感染，绝大多数胎儿预后良好。

Prenatal Diagnosis and Prognosis of Isolated Mild Fetal Cerebral Ventriculomegaly

Objective:To investigate the results of prenatal diagnosis and prognosis of isolated mild ventriculomegaly fetuses.Methods:Chromosomal karyotypes were retrospectively investigated in sixty one singleton fetuses with isolated mild ventriculomegaly.The outcome of fetuses was acquired through regular follow-up.Results:In 61 cases of isolated mild ventriculomegaly,3(4.92%) chromosomal aberrations were detected,including 2 Down syndrome and 1 trisomy sex chromosome.In 50 cases which the IgM of toxoplasma,cytomegalovirus and rubella virus was detected,one case was positive with rubella virus IgM.Follow-up was successful in 55 cases,8 were terminated because of various causes,including 3 chromosomal aberrations and 1 rubella IgM positive case.In 47 alive cases,1 was found to have multi-maformation after birth,1 died in neonatal period,2 with developmental retardation,43 cases(91.49%) with normal development.Conclusions:Prenatal diagnosis is necessary for the fetuses with isolated mild ventriculomegaly.Apart from chromosome aberration and congenital infection,most of isolated mild ventriculomegaly fetuses have good prognosis.