多囊卵巢综合征的基因多态性研究进展

多囊卵巢综合征(PCOS)是育龄期妇女的常见疾病,具有高雄激素、高胰岛素和胰岛素抵抗等特征。PCOS是妇科内分泌疾病中最具争议的疾病之一,其家族遗传特性已被证明,但目前可能参与其发病的基因尚未完全阐明,并且没有广为接受的PCOS基础致病基因。PCOS的异质性使研究更加困难,目前研究的基因主要是影响雄激素生物合成、转运、作用和调节的基因,与胰岛素抵抗和相关异常有关的基因以及与慢性炎症相关的基因。

The Gene Polymorphism Research Review of Polycystic Ovary Syndrome

Polycystic ovary syndrome(PCOS)is a common disease in women of child-bearing age,characterized by the presence of hyperandrogenism,insulin resistance,and hyperinsulinism.PCOS is one of the most controversial entities in gynecological endocrinology,and it has been proven to be a familial inheritance.However,up to date,genes that may be involved in the etiology of PCOS have not been fully investigated,and no gene has been universally accepted as the fundamental pathogenic gene.Because of the heterogeneity of the syndrome,research becomes more difficult.Till now the genes investigated are mainly related to the regulation of androgen biosynthesis and function,insulin resistance,and chronic inflammation.