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| 乳腺癌动态增强MRI表现与病理、分子预后指标的相关性分析 | |
| 引用本文： | 徐慧,贾文霄,周梅.乳腺癌动态增强MRI表现与病理、分子预后指标的相关性分析[J].中国医学影像学杂志,2011,19(2):121-128. |
| 作者姓名： | 徐慧 贾文霄 周梅 |
| 作者单位： | 1. 新疆医科大学附属肿瘤医院磁共振室,新疆乌鲁木齐,830011 2. 新疆医科大学第二附属医院影像中心,新疆乌鲁木齐,830063 3. 新疆医科大学附属肿瘤医院病理科,新疆乌鲁木齐,830011 |
| 基金项目： | 乌鲁木齐市第一批科技开发计划项目资助(编号:Y08131008) |
| 摘 要： | 目的:探讨乳腺癌磁共振动态增强表现与病理、分子预后指标之间的相关性。材料和方法:对104例原发性乳腺癌患者术前行乳腺MR扫描,根据MRI乳腺影像报告和数据系统(BI-RADS)描述乳腺癌的形态学和血流动力学表现。术后标本检测分析肿瘤大小、淋巴结状态和组织学分级并行免疫组化染色测定癌细胞雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、CerbB-2、Ki-67以及nm23的表达情况,采用Spearman等级相关和二元Logistic回归统计学方法分析与MRI表现的相关性。结果:形态不规则的肿瘤体积较大(P<0.001);肿瘤形态不规则形能预测ER阴性表达(P=0.035);环形强化是ER及PR阴性表达的预测因子(P=0.022,P=0.012);肿瘤信号增强率(SER)可以预测淋巴结状态(P=0.003),且SERmax值>133%易发生淋巴结转移。结论:乳腺癌MRI形态学和血流动力学表现与病理、分子预后指标之间存在一定相关性,可根据乳腺癌MRI表现对乳腺癌病灶的生物学行为和预后进行评估。肿瘤形态不规则、环形强化常提示患者预后不良。 |
| 关 键 词： | 乳腺肿瘤 磁共振成像 病理学 外科 预后 |
Correlation Between Dynamic MR Features and Pathology,Prognostic Factors in Breast Cancer |
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| XU Hui,JIA Wenxiao,ZHOU Mei.Correlation Between Dynamic MR Features and Pathology,Prognostic Factors in Breast Cancer[J].Chinese Journal of Medical Imaging,2011,19(2):121-128. | |
| Authors: | XU Hui JIA Wenxiao ZHOU Mei |
| Institution: | XU Hui JIA Wenxiao ZHOU Mei Department of MRI,Tumor Hospital of Xinjiang Medical University Wulumuqi,Xinjiang 830011 |
| Abstract: | Purpose To correlate dynamic contrast-enhanced MR features with pathology,prognostic factors in breast cancer.Materials and Methods 104 cases with primary breast cancer underwent dynamic contrast-enhanced MR prior to surgery.Morphologic and kinetic features of breast cancer were determined based on the breast imaging and reporting data system(BI-RADS). Histological specimens were analyzed after surgery for tumor size,axillary lymph node status,histological grade,expression of estrogen receptor(ER),expressio... |
| Keywords: | breast neoplasms magnetic resonance imaging pathology surgical prognosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |