胃癌神经侵犯与预后的相关性分析

目的探讨胃癌神经侵犯(Perineural invasion PNI)与胃癌预后的相关性。方法回顾性分析328例胃癌根治术后患者的临床病理资料(根据2002年日本肿瘤协会公布的JGC-TNM分期标准),研究神经侵犯与胃癌临床病理参数的关系及其对胃癌预后的意义。结果χ2检验结果显示:胃癌神经侵犯与浸润深度、TNM分期及淋巴结转移均显著相关(P<0.05)。单因素分析显示:PNI(+)组患者的中位生存时间及5年生存率明显低于PNI(-)组患者(P=0.018),与胃癌患者预后密切相关。多因素COX回归分析显示神经侵犯不是影响胃癌术后患者生存的独立预后因素(P=0.238)。结论胃癌神经侵犯与胃癌患者预后有关,并提示预后不良,但不能作为判断胃癌患者预后的独立指标。

Correlation Analysis of Perineural Invasion and Prognosis of Gastric Cancer

Objective To investigate the relation between perineural invasion（PNI） and prognosis of gastric cancer.Methods The clinical data of 328 patients who underwent radical gastrectomy were analyzed.The relation between perineural invasion and clinical pathological parameters,and its significance to the prognosis of gastric cancer were investigated.Results Perineural invasion was significantly related to depth of primary tumor invasion,lymph node metastasis and TNM stage（χ ^2 test,P〈0.05）.The median survival time and 5-year survival rate of the PNI-positive patients were significantly lower than those of PNI-negative patients in univariate analysis（P=0.018）,which were closely related with the prognosis of the patients.Multivariate analysis showed that perineural invasion was not an independent prognostic factor for the survival of patients with gastric cancer postoperative（p = 0.238）.Conclusion PNI is associated with the prognosis of patients with gastric cancer.Though it can indicate poor prognosis,it can not be used as an independent prognostic factor to determine the prognosis of patients with gastric cancer.