组织工程肌腱修复陈旧性跟腱断裂伴缺损的疗效观察

目的探讨应用组织工程肌腱修复陈旧性跟腱断裂伴缺损的手术方法及临床效果。方法1999年8月～2002年6月,采用同种异体肌腱来源的成纤维细胞,以5×106/ml细胞密度接种在医用碳纤维与聚羟基乙酸纤维制作的编织带上,体外培养5d后,修复跟腱缺损7例,缺损长度为5～7cm。术后踝跖屈外固定4～6周后开始功能锻炼。结果7例均获随访22～56个月,平均46.9个月。除1例术后伤口延迟愈合外,其余6例均期愈合。无全身及局部不良反应,无跟腱粘连再手术患者。按尹庆水疗效评定标准,优5例,良1例,可1例。结论组织工程肌腱修复跟腱缺损可获较好临床效果,是一种可选择的新治疗方法。

THERAPEUTIC EFFECT OF TISSUE ENGINEERED TENDON IN REPAIRING OLD CALCANEAL TENDON RUPTURE AND DEFECTS

Objective To probe into the surgical methods and therapeutic effect of repairing old calcaneal tendon rupture and defects with tissue engineered tendons. Methods The tissue engineered tendons were prefabricated by co-cultivating allogeneic tendon cells with composite of carbon fiber and polyglycolic acid for 5 days. From August 1999 to June 2002, 7 patients with calcaneal tendon rupture and defects (5-7 cm in length) were treated with tissue engineered tendons. The defects were repaired by suturing repeatedly with tissue engineered tendons. Meanwhile, the defects were covered by gastrocnemius fascial flap for protection and strengthening. After surgery, the ankle joints were fixed with plaster 4 to 6 weeks, and then the functional exercise was done. Results All the patients were followed up 22 to 56 months (46-9 months on average). Six patients achieved healing by the first intention, only one patient had delayed union. No local or systemic complication occurred in all the cases. No patients were given the second operation for adhesion. In accordance with YIN Qingshui's criterion for therapeutic effect, the results were excellent in 5 cases, good in 1 case and moderate in 1 case. Conclusion Repairing old rupture and defects of calcaneal tendon with tissue engineered tendons can achieve good clinical outcome, it is an optional therapy.