颈复汤对颈性眩晕患者血浆内皮素和降钙素基因相关肽水平影响的研究

目的观察颈复汤对颈性眩晕患者血浆内皮素(ET-1)、降钙素基因相关肽(CGRP)水平变化的影响及临床疗效。方法将170例确诊为颈性眩晕的患者随机分为颈复汤低剂量联合西药倍他司汀组(低结合组)、颈复汤中剂量联合西药倍他司汀组(中结合组)、颈复汤高剂量联合西药倍他司汀组(高结合组)、颈复汤中剂量组(中药组)、倍他司汀组,每组34例,疗程1周,用放射免疫法检测治疗前后血浆ET-1、CGRP水平变化,并进行积分评估。结果治疗后各组血浆ET-1水平显著下降,血浆CGRP水平和CGRP/ET-1比值显著提高。血浆ET-1水平各结合组与中药组相比有显著性差异(P均<0.05),血浆ET-1水平高结合组、中结合组与倍他司汀组比较有显著性差异。血浆CGRP水平高结合组、中结合组与中药组比较有显著性差异,高结合组与倍他司汀组、中结合组、低结合组比较有显著性差异。治疗后积分评估各组显著升高,低、中、高结合组与中药组比较具有显著性差异;高结合组、中结合组与倍他司汀组比较有显著性差异。结论血浆ET-1、CGRP可能是颈性眩晕发病的重要物质基础,两者失衡对颈性眩晕的发生发展起着重要作用。颈复汤可能通过对ET-1与CGRP水平的调整而起治疗作用,值得深入研究。

Research of the effect of Jingfutang on the level of plasma ET-1 and CGRP in cervical vertigo patients

Objective It is to observe the effect Jingfutang on the levels of plasma ET-1 and CGRP in patients with cervical vertigo.Methods 170 patients diagnosed with cervical vertigo randomly were divided into the TCM and western medicine group(low,medium and high doses were combined with Betahistine Hydrochloride Tablets),the TCM Jingfutang medium-dosage group and western medicine treatment group(Betahistine Hydrochloride Tablets).And there were totally 5 groups which consisted of 34 patients for each group and be treaed for 1 week,and finally using radiation immune method to detect the changes of plasma ET-1,CGRP levels and asses score before and after treatment.Results After treatment plasma ET-1 level decreased significantly,while the plasma CGRP level and CGRP/ET-1 ratio increased significantly in every group(P<0.05).After treatment there were significant differences in the levels of plasma ET-1 between TCM group and integrated groups.The differences between betahistine group and high and medium integrated groups were also significant.After treatment there were significant differences in the levels of plasma CGRP between TCM group and high and medium integrated groups.The differences between high integrated group and betahistine group,medium and low dose groups were also significant.After treatment,the integral assessment increased significantly in each group,there were significant differences in the scores between TCM group and integrated groups.The differences between betahistine group and high and medium integrated groups were also significant.Conclusion Plasma ET-1 and CGRP may be the material basis which can induce cervical vertigo,and the unbalance of them may plays an important role in the development of the disease.Jingfukang's treatment effect may be related to its improving effect on the levels of ET-1 and CGRP,which is worth deep study.