小剂量阿立哌唑合并帕罗西汀治疗难治性抑郁症的对照研究

目的探讨小剂量阿立哌唑联合帕罗西汀治疗难治性抑郁症的疗效与安全性。方法将64例难治性抑郁症患者随机分为治疗组(帕罗西汀合并阿立哌唑治疗)和对照组(单用帕罗西汀治疗),每组各32例,观察8周。于治疗前和治疗1周、2周、4周及8周末采用汉密尔顿抑郁量表(HAMD-17)评定疗效,用副反应量表(TESS)评定不良反应。结果治疗组显效率为68.75%,对照组为46.8%。治疗组从第2周末起HAMD分低于对照组,差异有统计学意义。两组间不良反应差异无统计学意义。结论阿立哌唑合并帕罗西汀治疗不伴精神病性症状的难治性抑郁症较单用帕罗西汀的疗效好,不良反应少。

Aripiprazole Combined with Paroxetine in the Treatment of Treatment Resistant Depression

Objective To explore the effect of Aripiprazole combined with paroxetine in the treatment of treatment resistant depression.Method 64 patients with treatment resistant depression were randomly assigned into two groups,aripiprazole combined with paroxetine and paroxetine alone for 8 weeks.The clinical eff icacy were evaluated by the Hamilton depressive scale（HAMD）.Adverse events were evaluated by the treatment emergent symptom scale（TESS） and related laboratory examinations.Results As compared with patients treated with paroxetine alone,the HAMD scores of the patients treated by combination of aripiprazole with paroxetine decreased signif icantly after 2 weeks treatment（P0.05）.After treatment,68.75% of the patients treated by combination of aripiprazole with paroxetine were effectual,and 46.8% of the patients treated with paroxetine alone.Conclusion The combination of aripiprazole with paroxetine is better than paroxetine alone in the treatment of treatment resistant depression.