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MMP-2及TIMP-2表达在良恶性葡萄胎鉴别诊断中的价值探讨
引用本文:张金库,闫国华,李玉兰,杨永滨,张祥宏.MMP-2及TIMP-2表达在良恶性葡萄胎鉴别诊断中的价值探讨[J].中国肿瘤临床,2001,28(5):333-335.
作者姓名:张金库  闫国华  李玉兰  杨永滨  张祥宏
作者单位:1. 保定市第一中心医院病理科,
2. 河北职工医学院附属医院病理科
3. 河北职工医学院病理教研室
4. 河北医科大学基础所病理研究所
基金项目:本文课题受保定市科委科技进步项目基金资助
摘    要:目的:寻求一种能早期诊断恶性葡萄的新方法,方法:采用免疫组化法观察良恶性葡萄胎组织中MMP-2及TIMP-2的表达情况。结果:MMP-2在恶性葡萄胎和良性葡萄胎的阳性率分别为73.3%和20.05(P<0.01);TIMP-2为33.3%和26.7%(P>0.05)。结论:MMP-2检测可作为鉴别良恶性葡萄胎的重要参考指标。

关 键 词:基质金属蛋白酶  金属蛋白酶组织抑制剂  葡萄胎  鉴别诊断  免疫组织化学  MMP-2  TIMP-2
文章编号:1000-8179(2001)05-0333-03
修稿时间:2000年8月24日

Diagnostic Significance of Expression of MMP-2 and TIMP-2 in Hydatidiform Mole and Malignant Mole
Zhang Jinku Yan Guohua Li Yulan et al.Diagnostic Significance of Expression of MMP-2 and TIMP-2 in Hydatidiform Mole and Malignant Mole[J].Chinese Journal of Clinical Oncology,2001,28(5):333-335.
Authors:Zhang Jinku Yan Guohua Li Yulan
Institution:Zhang Jinku Yan Guohua Li Yulan et al Department of Pathology,First Central Hospital,Baoding
Abstract:Objective: To explore a new method in early diagnosis of malignant mole. Methods: The changes of expression of MMP-2 and TIMP-2 were deterted in hydatidiform and malignant mole by immunohistochemistry. Results: The results revealed that the positive rate of MMP-2 in hydatidiform mole was significantly higher than that in malignant mole (P<0.01), but there was no significant difference in positive rate of TIMP-2 between hydatidiform moles and malignant moles (P>0.05). Conclusion: MMP-2 can be regarded as the important signal to discriminate the hydatidiform mole and malignant mole.
Keywords:Matrix metalloproteinases  Tissue inhibitor of metalloproteinases Hydatidiform mole  Malignant mole  Diagnosis Immunohistochemistry
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