小儿不同CRP水平呼吸道疾病肺炎支原体感染情况分析

目的 研究小儿不同C反应蛋白(CRP)水平呼吸道疾病肺炎支原体感染的情况,为临床诊断肺炎支原体感染提供参考依据.方法 对2011年3月至2012年2月湛江市妇幼保健院收治的呼吸道感染疾病住院患儿,每月随机抽取50例,合计600例,记录下患儿的年龄、发病季节、入院时诊断,并在入院时检测患儿CRP与肺炎支原体抗体(MP-IgM)水平,分析比较不同CRP水平下不同呼吸道疾病组、不同年龄组、不同季节组肺炎支原体感染率(MP-IgM阳性率)情况.结果 CRP正常组MP-IgM阳性率显著高于CRP异常组(P＜0.05).CRP正常水平时MP-IgM阳性率:婴幼儿组较年长儿组高,秋季组与冬季组较春季组高,支气管肺炎组(肺炎组)与毛细支气管炎组(毛支组)较急性上呼吸道感染组(上感组)高,毛支组较急性支气管炎组(支炎组)高,差异均有统计学意义(P＜0.05).CRP异常水平时MP-IgM阳性率:婴幼儿组与年长儿组及不同季节组之间差异均无统计学意义(P＞0.05)；肺炎组较上感组与支炎组高,差异有统计学意义(P＜0.05).结论 CRP正常水平下,婴幼儿、秋冬季、肺炎、毛细支气管炎肺炎支原体感染率高;CRP异常水平下,肺炎、毛细支气管炎肺炎支原体感染率高,临床上均要加强检测,及早诊断与治疗,以减少肺炎支原体所引起的并发症.

Mycoplasma Infection in Different C-reactive Protein Levels of Respiratory Disease

Objective To study the mycoplasma pneumoniae infection in different C-reactive protein （CRP） levels of respiratory disease, and to provide a reference for the clinical diagnosis of mycoplasma pneumoniae infection. Methods The child age, onset seasons and admission diagnosis were recorded in 600 children with respiratory tract infection who were treated in Zhanjian Maternity and Child Health Care Hospital between March 2011 and February 2012 （50 children per month）. The levels of CRP and mycoplasma pneumoniae-specific IgM （MP-IgM）were measured on admission. The positive rate of MP-IgM was compared among different respiratory disease groups, as well as different age groups and different season groups. Results The positive rate of MP-IgM in normal CRP group was higher than that in abnormal CRP group（P〈0.05）.In children with normal CRP levels, the positive rates of MP-IgM in infant group, autumn or winter group, pneumonia group and bronchiolitis group were higher than those in older child group, spring group and bronchitis group, respectively（P〈0.05）.In chi- ldren with abnormal CRP levels, no significant differences in the positive rate of MP-IgM were found between infant group and older child group and among different season groups （P〉0.05）, but the positi- ve rate of MP-IgM in pneumonia group was obviously higher than that in upper respiratory tract infection group or bronchiolitis group（P〈0.05）. Conclusion Among children with normal CRP levels,infants, autumn and winter seasons, pneumonia, and bronchitis are the risk factors for mycoplasma pneumoniae infection. Among children with abnormal CRP levels, pneumonia and bronchiolitis are the risk factors for mycoplasma pneumoniae infection. Therefore, correlative detection should be strengthened and early diagnosis and treatment should be performed to reduce the complications of mycoplasma pneumoniae infection.