A型肉毒毒素缓解脑瘫儿童小腿三头肌痉挛最佳剂量研究

目的确定治疗脑瘫痉挛的理想A型肉毒毒素(BTX-A)剂量计算公式中的系数。方法将58例脑瘫患儿(男性38例、女性20例,年龄27～144个月,平均59.3±24.6个月)按剂量系数分为A、B、C、D、E五组,给予不同剂量的BTX-A治疗。结果从运动功能改善的角度考虑,D组的BTX-A剂量比较适合;从疗效持续时间的角度考虑,C组的BTX-A剂量比较适合,理想的系数应为1.8。结论小腿三头肌初次BTX-A理想剂量的计算公式应为:剂量(I U)=(1+1.8×MAS评分)×体重(kg)。

Optimal Dose of Botulinum Toxin A to Release Spasticity of Triceps Surae in Children with Cerebral Palsy

Objective To determine the coefficient in the formula of the optimal dose of botulinum toxin A(BTX-A) to treat spastic cerebral palsy(CP).Methods58 CP children(male 38,female 20,mean age 59.3±24.6 months,range 27 to 144 months) were divided into A,B,C,D and E five groups according to used coefficient and treated by BTX-A with different doses to release the spasticity.ResultsAccording to the improvement of motor function,the BTX-A dose of the group D was optimal.According to the effective endurance,the BTX-A dose of the group C was optimal.The optimal coefficient was 1.8.ConclusionThe formula of the optimal BTX-A dose injected in triceps surae is dose =(1+1.8×MAS score)×body weight.