| 橄榄星小单孢菌发酵培养基及发酵条件的优化 |
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| 引用本文： | 王名堂,谢莉莉,林玉双,洪文荣.橄榄星小单孢菌发酵培养基及发酵条件的优化[J].海峡药学,2010,22(4):167-170. |
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| 作者姓名： | 王名堂 谢莉莉 林玉双 洪文荣 |
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| 作者单位： | 福州大学生物科学与工程学院,福州,350108 |
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| 摘 要： | 本文对产福提霉素的橄揽星小单抱菌H3—25进行发酵培养基和发酵条件的优化，确定了发酵培养基的适宜配比为：可溶性淀粉4％。葡萄糖1％，酵母粉4％，硫酸镁0．1％．碳酸钙0．1％，氯化钴2μg·L^-1，甘氨酸0．1％；最佳发酵条件为：初始pH7．0，培养温度32℃，移种时间36h，移种量10％，摇瓶装量50mL／250mL，发酵周期8乩
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| 关 键 词： | 福提霉素 培养基 发酵条件 优化 |
Researches on fermentation medium and fermentation conditions of Micromonospora olivoasterospora |
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| WANG Ming-tang,XIE Li-li,LIN Yu-shuang,HONG Wen-rong.Researches on fermentation medium and fermentation conditions of Micromonospora olivoasterospora[J].Strait Pharmaceutical Journal,2010,22(4):167-170. |
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| Authors: | WANG Ming-tang XIE Li-li LIN Yu-shuang HONG Wen-rong |
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| Institution: | (College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China) |
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| Abstract: | The fermentation process for fortimicin was optimized by single factor tests and orthogonal tests. Finally, the medium composition and fermentation conditions were optimized as followssoluble starch 4 %, glucose 1%, yeast powder 4 %, MgSO4 0.1%, CaCO3 0.1%, CoCl2μg·L^-1, glycine 0.1%, pH 7.0, temperature 32℃, inoculum time 36 hours, inoculum volume 10 %, the optimum amount in flask 50/250（mL） and fermentation period 8 days. |
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| Keywords: | Fortimicin Medium Fermentation condition Opitimization |
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