消栓口服液质量标准的研究

目的：制订消栓口服液的质量控制方法。方法：采用TLC法对处方中的赤芍、当归、川芎进行了定性鉴别,采用HPLC法对处方中黄芪进行了含量测定,以CAPCELL PAK C18柱（250 mm×4.6 mm,5μm）为分析柱,以乙腈-水（35∶65）为流动相,流速为1.0 ml/min,蒸发光散射检测器。结果：赤芍、当归、川芎可用薄层色谱鉴别;黄芪甲苷进样量在1.2795~12.795μg范围内进样量的自然对数与峰面积的自然对数呈良好的线性关系（r=0.9998）;平均回收率（n=9）为101.25%,RSD为1.91%。结论：该方法准确灵敏、简便,重复性好,提高后的质量标准更有效的控制该制剂的质量。

Study on Quality of Xiaoshuan oral Liquid

Objective：To establish the method for quality control of Xiaoshuan oral liquid.Methods：Radix paeoniae rubra ,Radix angelicae sinensis and Rhizoma chuanxiong in Xiaoshuan oral liquid were identified by TLC,Astragaloside Ⅳ was determined by HPLC.A CAPCELL PAK C18 column（250 mm×4.6 mm,5 μm）was adoped.The mobile phase was acetonitrile-water（35∶65）,at the flow rate of 1.0 ml/min and ELSD.Results：The linearity was obtained within the range of（1.2795～12.795） μg（r=0.9998）;The average recovery（n=9） was 101.25%,and RSD was 1.91%.Radix paeoniae rubra,Radix angelicae sinensis and rhizoma chuanxiong can be identified by TLC.Conclusion：The method is convenient,accurate,reproducible,and can be used for quality control of the preparation.