Supratentorial glioblastoma in adults: Identification of subsets and their clinical correlation |
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Authors: | Email author" target="_blank">Chitra?SarkarEmail author Subrata?Sinha Mehar?Chand?Sharma Rajender?Kumar Veer?Singh?Mehta |
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Institution: | (1) Room No. 1083, 1st Floor, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029 New Delhi, India;(2) Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India;(3) Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India |
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Abstract: | The concept of different genetic pathways leading to glioblastoma multiforme (GBM) has gained considerable acceptance, and
two major groups are now described, primary or de novo GBM and secondary GBM. The present study was undertaken to elucidate
whether additional pathways exist and to determine whether there is any correlation between these different variants and clinical
parameters, such as age, duration of symptoms, and outcome. For this purpose, immunophenotyping was performed to study the
simultaneous expression of p53 protein and epidermal growth factor receptor (EGFR) in 58 cases of adult supratentorial GBM.
By this method, four variants of GBM could be distinguished: 34% were p53 positive only, 38% were EGFR positive only, 14%
were double negative (p53 negative/EGFR negative), and 14% were double positive (p53 positive/EGFR positive). Interestingly,
all nine cases of secondary GBM in which there was clinical and histological evidence of progression from a preexisting low-grade
lesion were p53 positive. Differences were observed with regard to the age distribution of the four variants, in that the
p53 negative/EGFR negative tumors occurred most frequently in the younger age group (21–40 years). In the elderly group (61–80
years), two-thirds of the tumors were p53 negative/EGFR positive primary GBMs, and no case of the double positive or double
negative variant was encountered. The differences in duration of symptoms and symptom-free survival according to age group
and genetic subset were not statistically significant. There were no differences in outcome within each age category for any
GBM variant, although the longest mean symptom-free survival was noted among patients aged 41–60 years with the p53 positive/EGFR
negative variant. This study therefore indicates that at least four subsets of GBM exist, but despite different genotypes,
the biologic behavior remains similar. Other genetic alterations therefore need to be investigated to identify prognostic
makers. |
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Keywords: | Supratentorial Adult GBM p53 EGFR Subsets Age Survival |
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