Ezrin和survivin在非小细胞肺癌的表达及其相关性

 目的 探讨Ezrin和survivin在非小细胞肺癌（NSCLC）组织中的表达情况及其相关性。方法 利用免疫组织化（Envision法）对86例非小细胞肺癌组织石蜡标本进行Ezrin和survivin蛋白表达的检测和分析。结果 非小细胞肺癌中Ezrin蛋白高表达率为60.5%（52/86），其与患者有无淋巴结转移密切相关（P<0.05），与性别、肿瘤组织学类型、分化程度、临床TNM分期、吸烟无明显相关性（P>0.05），survivin的阳性表达率为65.1%(56/86)，并且与患者临床TNM分期、有无淋巴结转移密切相关（P<0.05），与性别、肿瘤组织学类型、分化程度、吸烟无关（P>0.05），同时，Ezrin和survivin表达呈显著正相关（r=0.384）。结论 Ezrin和survivin在NSCLC的发生发展中具有协同作用，其表达与非小细胞肺癌转移密切相关，两者联合有助于判断肿瘤转移和为临床治疗提供参考依据。

Expression and Correlation of Ezrin and survivin in Non-small Cell Lung Cancer

Objective To study the Ezrin and survivin expression and their correlation and clinical significances in NSCLC. Methods The expression of Ezrin and survivin were detected in 86 NSCLC by Envision method of immunohistochemical staining. Their relations with the clinical pathologic and other characters were analyzed. Results The high expression rate of Ezrin in non-small cell lung cancer was 60.5 and significantly correlated with lymph node metastasis(P<0.05), but not associated with gender, histologic subtype, TNM stages, differentiation and smoking. Meanwhile, the high expression rate of survivin in non-small cell lung cancer was 65.1% and significantly correlated with TNM stages and lymph node metastasis(P<0.05), while not associated with gender, histologic subtype, differentiation and smoking.The expression of Ezrin and survivin was coincident in NSCLC (r=0.384). Conclusion Ezrin and survivin might play synergetic roles in the process of carcinogenesis of NSCLC. Their expression may be close associated with non-small cell lung cancer metastasis, combination detection of Ezrin and survivin may be valuable for diagnosing lung cancer metastasis and providing evidence for clinical treatment.