| 微波法合成奥沙普秦 |
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| 引用本文： | 温新民,张波,王惠云.微波法合成奥沙普秦[J].济宁医学院学报,2006,29(1):10-11. |
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| 作者姓名： | 温新民 张波 王惠云 |
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| 作者单位： | 济宁医学院化学教研室 |
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| 摘 要： | 目的合成非甾体类抗炎药奥沙普秦。方法以安息香为起始原料,采用微波辐射下的一锅工艺快速合成奥沙普秦。结果全程反应时间由常规条件下的5h缩短为10min,收率由常规方法的63%提高到72%。结论微波法合成奥沙普秦产率高,速度快。
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| 关 键 词： | 微波辐射 合成 奥沙普秦 |
| 收稿时间： | 2006-01-04 |
| 修稿时间： | 2006-01-04 |
Synthesis of Oxaprozin Under Microwave Irradiation |
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| WEN Xinmin,ZHANG Bo,WANG Huiyun.Synthesis of Oxaprozin Under Microwave Irradiation[J].Jounal of Jinning Medical College,2006,29(1):10-11. |
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| Authors: | WEN Xinmin ZHANG Bo WANG Huiyun |
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| Institution: | Department of Chemistry,Jining Medical College |
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| Abstract: | Objective To synthesize nonsteroidal anti-inflammatory drug oxaprozin.Methods oxaprozin was synthesized by the microwave irradiation in one-pot reaction.Results The yield of the oxaprozin was increased from 63% to 72% and the time was shortened from 5h to 10min.Conclusion The microwave irradiation accelerated the reactions siynificartly and the yield was increased. |
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| Keywords: | Microwave irradiation Synthesis Oxaprozin |
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