精神分裂症患者临床特征和无抽搐电痉挛治疗刺激参数对疗效影响

目的探讨无抽搐电痉挛治疗精神分裂症时患者临床特点及刺激参数与疗效的相关性,为无抽搐电痉挛个性化治疗方案的制定提供参考依据。方法共入组58例精神分裂症患者,给予无抽搐电痉挛治疗8次,使用自编临床资料记录表记录患者社会人口学资料、临床特征、无抽搐电痉挛刺激参数等资料,采用阳性和阴性症状量表(PANSS)评估疗效。结果依据治疗结束时PANSS评分减分率65%分为显著好转组(≥65%)和非显著好转组(65%),共有如下因素纳入回归方程:年龄(回归系数为0.13)、性别(回归系数为2.84)、发病年龄(回归系数为-0.18)、MECT峰值强度(回归系数为0.00)、MECT发作时间(回归系数为0.09)、治疗前阴性症状(回归系数为-0.42)、攻击症状(回归系数为-0.95)、PANSS总分(回归系数为0.13)。结论患者年龄大、女性、发病年龄晚、峰值强度大、发作时间长、阴性症状轻、攻击症状轻、病情重的患者无抽搐电痉挛治疗效果好。

Clinical Characteristics of Schizophrenia and the Effect of Stimulation Parameters of MECT on Efficacy

Objective To explore the clinical features of schizophrenia patients and effect of stimulation parameters of MECT on treatment efficacy .Methods A total of 58 schizophrenia patients were recruited and treated with MECT for 8 times.Self-designed case report form was used to collect demographic data ,clinical characteristics of the patients and stimulation parameters of MECT .The positive and negative symptom scale （ PANSS） was used to assess treatment efficacy .Results According to reducing rate of PANSS at the end of treatment ,patients were divided to significantly improved group （≥65%） and non significantly improved group （〈65%） .Logistic analysis suggested that factors entered into the regression equation were as follows：Age（regression coefficient was 0.13）,gender（regression coefficient was 2.84）,age of onset（regression coefficient was-0.18）,MECT peak intensity（regression coefficient was 0）,MECT convulsive time（regression coefficient was 0.09）,negative symptoms（regression coefficient was-0.42）,attack symptoms（regression coefficient was-0.95）,PANSS score（regression coefficient was 0.13）.Conclusion Age,female,age of onset,peak intensity,convulsive time,negative symptoms and attack symptom are associated with the efficacy of MECT .