银杏叶制剂对蛛网膜下腔出血大鼠血浆及脑组织内皮素-1含量的影响

目的探讨蛛网膜下腔出血（ＳＡＨ）后内皮素－１（ＥＴ－１）变化和银杏叶制剂（ＧＢＥ）对其影响。方法对单纯ＳＡＨ组和ＧＢＥ处理组大鼠检测ＳＡＨ后２４ｈ内颅内血浆及脑组织ＥＴ－１含量的动态改变。结果 ＳＡＨ组血浆及脑组织 ＥＴ－１含量分别于 ＳＡＨ后即刻和 １ｈ明显增加，并维持 ２４ｈ（Ｐ＜０．０５，０．０１）。ＧＢＥ组ＳＡＨ后ＥＴ－１增加的程度显著小于ＳＡＨ组（Ｐ＜０．０５，０．０１）。结论血浆及脑组织ＥＴ－１增多可能是造成脑部大血管和微血管痉挛及其缺血性脑损伤的原因之一，ＧＢＥ则可逆转ＥＴ－１的上述病理性改变。

Effects of Ginkgo Biloba Extract on Endothelin-1 Levels in Plasma and Brain Tissue in Rats with Subarachnoid Hemorrhage

Objective To investigate the changes of endothelin-1 (ET-1) after subaracbnoid hemorrhage (SAH) and the effects of Ginkgo biloba extract. Methods SAH models were made using Wistar rats and were divided into pure SAH group and GBE treated group. Dynamic changes of ET-1 levels in both intracranial plasma and brain tissue in all rats were detected within 24h after SAH. Results ET-1 lelvels in plasma and brain tissue in SAH group increased immediately and from 1h after SAH respectively,maintaining 24h (P<0.05. 0. 01). ET-1 levels in both plasma and brain tissue in GBE treated group were lower than those in SAH group (P<0.05, 0.01). Conclusions increase of ET-1 concentrations in plasma and brain tissue is involved in the development of cerebral vasospasm and relat ed brain ischemic damage after SAH. GBE may reverse the pathological changes of ET-1.