Clear cell odontogenic tumour: a case with induction of dentin-like structures? |
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Authors: | Mutsumi Miyauchi Ikuko Ogawa Takashi Takata Hiroshi Ito Hiromasa Nikai Naokuni Ijuhin Keiji Tanimoto Yoshiaki Itoh |
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Institution: | Department of Oral Pathology, Hiroshima University School of Dentistry, Hiroshima 734-8553, Japan;Clinical Laboratory, Hiroshima University Dental Hospital, Hiroshima 734-8553, Japan;Department of Oral Pathology, Osaka University Faculty of Dentistry, Hiroshima 734-8553, Japan;Department of Oral and Maxillofacial Radiology, Hiroshima University School of Dentistry, Hiroshima 734-8553, Japan;Department of Oral and Maxillofacial Surgery II, Hiroshima University School of Dentistry, Hiroshima, Hiroshima 734-8553, Japan |
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Abstract: | A case of clear cell odontogenic tumour, which occurred centrally in the mandible of a 56-year-old Japanese woman, is reported with its histochemical, immunohistochemical and ultrastructural findings. Histologically, the tumour nests were composed of large glycogen-rich clear cells and small non-clear polygonal cells and were separated by thin mature fibrous connective tissue septae. Immunohistochemically, both types of tumour cells showed positive expression of various cytokeratins, in particular cytokeratin 19, and of epithelial membrane antigen. Eosinophilic hyaline deposits and possible dentin-like structures were occasionally formed in contact with the epithelial nests and are regarded as indicative of the epithelial-mesenchymal inductive capacity of this tumour. The aggressive nature of the present tumour was assumed through its invasive growth pattern and occasional mitotic figures. Although it was diagnosed as clear cell odontogenic tumour according to the present WHO classification, the patient must be followed carefully because of its probable malignant nature. |
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Keywords: | Key words: clear cell odontogenic carcinoma clear cell odontogenic tumour epithelial-mesenchymal induction odontogenic tumour |
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