老年人脂蛋白脂酶活性改变及其与血脂水平的关系

目的 探讨老年人脂蛋白脂酶(LPL)活性改变及其与血脂浓度之间的关系.方法测定40例老年人甘油三酯、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及肝素后LPL活性,以45例非老年人作为对照,并用直线相关回归研究LPL活性与血脂水平的关系.结果老年人甘油三酯、总胆固醇及LDL-C浓度均显著高于非老年人(P<0.05或<0.01);肝素后LPL活性明显低于非老年人(P<0.05);老年人肝素后LPL活性与甘油三酯浓度呈负相关(r=-0.513,P<0.01),与HDL-C水平则呈正相关(r=0.390,P<0.05).结论老年人LPL活性降低会引起高甘油三酯血症伴有低HDL-C浓度,并可能是一种导致动脉粥样硬化的危险因素.

Lipoprotein lipase activity anti its relationship to serum lipid levels in elderly

Objective To evaluate lipoprotein lipase (LPL) activity and its relationship to serum lipid. Methods Serum triglyceride (TG) ,total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and postheparin LPL activity in 40 elderly subjects and 45 subjects in control group. Results TG,TC and LDL-C levels were much higher in the elderly than in control group (P <0.05 orP <0.01) ;postheparin LPL activity was lower in elderly (P <0.05) ; and showed a negative correlation with serum TG level (r = -0. 513 ,P < 0.01), but was positively correlated with serum HDL-C concentration (r = 0. 390, P < 0.05). Conclusion The decreased activity of LPL in the elderly may contribute to hypertriglyceridemia associated with low level of high density lipoprotein cholesterol, and could be a risk factor for atherosclerosis.