胎儿胰胸腺联合移植治疗Ⅰ型糖尿病(附10例1年以上疗效观察)

应用胎儿胰腺及胸腺联合移植治疗Ⅰ型糖尿病10例,随访时间1年以上,效果满意。显效7例,其中2例停用胰岛素,5例胰岛素平均减量82％。有效3例,胰岛素平均减量56.9％。10例受者植后2个月、半年及1年胰岛素平均减量分别为68.3％、74.5％及78.4％。1年有效率100％。对不同热缺血时间供体组织进行了超微结构观察,重点讨论了联合移植的意义及联合取材技术与移植效果的关系。

COMBINED TRANSPLANTATION OF FETAL PANCREAS AND THYMUS FOR THE TREATMENT OF DIABETES MELLITUS I: A REPORT OF ONE-YEAR OBSERVATION

Combined transplantation of fetal pancreas and thymus was performed in 10 patients suffering from severe diabetes I. They were closely followed for over one year, and it was found that among them 7 showed spectacular clinical improvement, including 2 with total discontinuation of insulin, and 5 with average reduction of insulin by 82%. In 3 patients, the dosage of insulin was reduced by an average of 56.9%. The average reduction of insulin for the 10 patients in 2 months, 6 months and one year after the transplantation was 68.3%, 74.5%, and 78.4%, respectively. The effect of warm ischemia of different durations on the donor tissues was studied with electron microscopy. The significance of combined transplantation and the relationship of the techniques of procuring the donor tissues and transplantation is discussed.