Antihypoxic effects of derivative on the EEG power spectra in rats with different susceptibility to oxygen deficiency |
| |
Authors: | L D Luk'yanova A Yu Malyshev S V Krapivin |
| |
Institution: | (1) Laboratory of Bioenergetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
| |
Abstract: | The succinate-containing hydroxypyridine derivative yancarb increases both the altitude tolerated by rats and their survival
time at a high altitude, particularly in rats with low resistance to hypobaric hypoxia; it also prevents both phasic changes
in the EEG characteristic of hypobaric hypoxia and hemispheric asymmetry and paroxysmal activity in the brain of highly resistant
rats in the 5000–10,000 m range and in rats with low resistance in the 5000–11,000 m range. Antihypoxic effects of this substance
are more pronounced in low-resistance rats and in the left hemisphere of both high- and low-resistant animals; in altitude
range of 10,000–13,000 m these effects are weaker or absent.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 57–62, July, 1997 |
| |
Keywords: | Cerebral cortex Fourier EEG power spectra hypobaric hypoxia antihypoxants succinate-containing hydrooxypyridine derivative |
本文献已被 SpringerLink 等数据库收录! |
|