Differential block by troglitazone and rosiglitazone of glibenclamide-sensitive K(+) current in rat aorta myocytes |
| |
Authors: | Mishra S K Aaronson P I |
| |
Institution: | Department of Pharmacology, The Guy's, King's College and St Thomas' Hospitals' Medical and Dental School, St Thomas's Campus, Lambeth Palace Road, London, UK. |
| |
Abstract: | Thiazolidinediones are insulin-sensitising agents effective in controlling type II diabetes. These compounds also cause vasodilation. We evaluated the effects of the thiazolidinediones troglitazone and rosiglitazone on the glibenclamide-sensitive K(+) current in freshly isolated rat aorta myocytes. Troglitazone inhibited this current in a concentration-dependent manner (IC(50) approximately 1 microM). Rosiglitazone had a similar, but much less potent (IC(50) approximately 20 microM) action. Block of the glibenclamide-sensitive K(+) channels, in particular by troglitazone, may potentially affect the response of arteries to hypoxia and to certain endogenous and exogenous vasodilators. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|