Detection of human papillomavirus DNA in nongenital seborrhoeic keratoses |
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| Authors: | D. Tsambaos A. Monastirli N. Kapranos S. Georgiou E. Pasmatzi A. Stratigos H. Koutselini H. Berger |
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| Affiliation: | (1) Department of Dermatology, School of Medicine, University of Patras, GR-26500 Rio-Patras, Greece;(2) Department of Dermatology, University of Athens, Athens, Greece;(3) Department of Cytopathology, Evangelismos Hospital, Athens, Greece;(4) Department of Dermatology, University of Göttingen, Göttingen, Germany |
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| Abstract: | The histological similarities of seborrhoeic keratoses and common warts led to the investigation of the possible occurrence of human papillomavirus DNA (HPV-DNA) in a large number of nongenital seborrhoeic keratoses using the in situ hybridization technique. All specimens derived from normal skin (n=173) were negative for the applied HPV-DNA probe, whereas the HPV genome was detected in 34 of 173 seborrhoeic keratosis specimens (19.65%). Of 34 HPV-positive specimens, 15 contained types 6/11 and 14 types 31/33/35, and 5 showed no positive reaction to the applied types. These results suggest that a considerable percentage of nongenital seborrhoeic keratoses may be related to an HPV infection.Dedicated to Professor Dr. H. Ippen on the occasion of his 70th birthday |
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| Keywords: | Hybridization technique in situ Papillomavirus Seborrhoeic keratosis |
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