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Results of combined therapy of irradiation and intra-arterial one-shot injection of cisplatin for head and neck cancers
Authors:Y Mariya  S Watanabe  Y Yokoyama  S Takahashi  K Kattou  N Tarusawa  K Tarusawa  Y Saikawa  K Kamada  H Yodono
Institution:Dept. of Radiology, Aomori Prefectural Central Hospital.
Abstract:Thirty-six previously untreated cases of head and neck cancer were given a combined therapy of irradiation and intra-arterial, one-shot injection of Cisplatin. As a result, the primary lesions in 35 cases were seen to achieve a 66% complete remission (CR) and a 100% overall response (OR). The lymph metastases in twenty-one cases with positive node achieved a 62% CR and a 100% OR. Good, local control of supraglottic and hypopharyngeal cancers were found to be an advantageous factor considered from the standpoint of the "quality of life". The cumulative survival rate, using Kaplan-Meier's method, was 82% for the first year, and 62% for the second year. No severe side effects were observed.
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