频繁单采血小板影响献血员巨核细胞的生成

为了探讨血小板单采对献血员巨核细胞生成的影响,于末次单采血小板5周后,检测42名频繁单采血小 板献血员(连续24个月内单采血小板≥1次／月,1次／治疗剂量≥2.5×1011血小板)和62名少量单采血小板献血 员(连续24个月内单采血小板<1次／月)以及40名未单采过血小板的健康无偿全血献血员(末次献血6个月后) 的外周血血小板计数和血浆血小板生成素(TPO)、IL-3、IL-6及NO水平。结果表明:频繁单采血小板献血员的血 浆TPO水平显著低于少量单采血小板献血员(P<0.01)和全血献血员(P<0.01);3组间的血小板计数、血浆IL- 3、IL-6和NO水平均无显著性差异。上述结果显示,频繁单采血小板献血员的骨髓巨核细胞数量明显增加。

Influence of Repeated Platelet Donation on Megakaryopoiesis in Donors

To explore influence of platelet donation on donor's megakaryocytopoiesis, platelet counts and plasma concentrations of thrombopoietin (TPO), interleukin-3 (IL-3), IL-6 and nitric oxide (NO) were determined in 42 frequent platelet donors (undergoing plateletpheresis more than once a month for 24 months and their mean platelet yield of collection was 2.5 x 10(11)), in 62 limited platelet donors (undergoing plateletpheresis less than once a month for 24 months) after a donation-free period of > 5 weeks and in 40 whole blood donors who never undergoing plateletpheresis after a donation-free period of > 6 months. The results showed that the TPO levels was significantly lower in frequent platelet donors than in limited platelet donors (P < 0.01) and whole blood donors (P < 0.01). There were no significant differences between three groups in platelet counts, IL-3, IL-6 and NO. These findings suggest that the number of megakarocytes significantly increased in frequent platelet donors.