RNA specific for the transforming component of avian erythroblastosis virus strain R. |
| |
| Authors: | T Kamahora H Sugiyama A Nomoto M Yoshida K Toyshima |
| |
| Affiliation: | 1. Department of Tumor Viruses, Research Institute for Microbial Diseases, Osaka University, Yamada-Kami, Suita, Osaka 565, Japan;2. School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Skirokane, Minato-Ku, Tokyo 108, Japan;3. Department of Viral Oncology, Cancer Institute, Kami-Ikebukuro, Toshima-Ku, Tokyo 170, Japan |
| |
| Abstract: | Avian erythroblastosis virus strain R (AEV) contains two species of RNA, 35 S and 30 S, when rescued from nonproducing AEV-transformed chicken cells as pseudotypes of Rous-associated virus-1 (RAV-1) or of AEV-associated virus (REAV). Biological and electrophoretic data suggest that the 30 S RNA is specific for the transforming component of AEV. In fingerprint analysis of RNase T1-resistant oligonucleotides the 30 S RNA of AEV(RAV-1) yields 13 distinct oligonucleotide spots, 7 of which are unique to the 30 S RNA of AEV, the others are common to RAV-1. The fingerprint of 30 S RNA obtained from AEV(REAV) revealed a similar pattern of unique and shared oligonucleotides. These data suggest that the genome of AEV strain R contains specific genetic sequences which may code for a product that causes transformation of the host cell. |
| |
| Keywords: | To whom reprint requests should be addressed. |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
