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18F-FDG PET/CT in the evaluation of POEMS syndrome |
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| Authors: | MA Albertí S Martinez-Yélamos A Fernandez C Gamez |
| Institution: | a Department of Neurology, Hospital Universitario de Bellvitge, C/Feixa Llarga s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain b PET unit, IDI, Hospital Universitario de Bellvitge, C/Feixa Llarga s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain c Department of Internal Medicine, Hospital Universitario de Bellvitge, C/Feixa Llarga s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain d Department of Radiology, Hospital Universitario de Bellvitge, C/Feixa Llarga s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain |
| Abstract: | In POEMS syndrome the identification and biopsy of an osteosclerotic lesion or a lymph node typical of Castleman's disease (CD) is essential to establish the diagnosis and plan appropriate treatment. We report four patients in whom the localisation and identification of diagnostic bone lesions or lymphadenopathies were guided by fluorodeoxyglucose positron emission tomography integrated with computerised tomography (FDG PET/CT). FDG PET/CT identified bone lesions not detected with other techniques in one patient, and revealed hypermetabolic characteristics in bone lesions or adenopathies in the others, thus guiding the diagnostic biopsy in those with hypermetabolism. In conclusion, FDG PET/CT may be useful in detecting and selecting bone lesions and lymph nodes for biopsy in patients with suspected POEMS syndrome. |
| Keywords: | Castleman's disease Computed tomography (CT) Osteosclerotic myeloma FDG PET/CT POEMS syndrome Positron emission tomography (PET) |
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