Percutaneous laser ablation of hepatocellular carcinoma in patients with liver cirrhosis awaiting liver transplantation |
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Authors: | Maurizio Pompili Claudio Maurizio Pacella Giampiero Francica Mario Angelico Giuseppe Tisone Paolo Craboledda Erica Nicolardi Gian Ludovico Rapaccini Giovanni Gasbarrini |
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Affiliation: | a Department of Internal Medicine, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Roma, Italy b Department of Diagnostic Imaging and Interventional Radiology, Ospedale Regina Apostolorum, Via S. Francesco D’Assisi, 50, 00041 Albano Laziale (RM), Italy c Department of Interventional Ultrasound, Presidio Ospedaliero Camilliani, S. Maria della Pietà, Via S. Rocco, 9, 80026 Casoria (NA), Italy d Hepatology Unit, Università di Tor Vergata, Viale Oxford, 81, 00133 Rome, Italy e Transplant and General Surgery Unit, Università di Tor Vergata, Ospedale S. Eugenio, Piazzale dell’Umanesimo 10-00144 Rome, Italy f Department of Pathology, Ospedale S. Eugenio, Piazzale dell’Umanesimo, 10-00144 Rome, Italy |
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Abstract: | ObjectiveThe aim of this study was to determine the effectiveness and safety of percutaneous laser ablation for the treatment of cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation.Materials and methodsThe data of 9 male cirrhotic patients (mean age 50 years, range 45-60 years) with 12 biopsy proven nodules of hepatocellular carcinoma (mean diameter 2.0 cm, range 1.0-3.0 cm) treated by laser ablation before liver transplantation between June 2000 and January 2006 were retrospectively reviewed. Laser ablation was carried out by inserting 300 nm optical fibers through 21-Gauge needles (from two to four) positioned under ultrasound guidance into the target lesions. A continuous wave Neodymium:Yttrium Aluminium Garnet laser was used. Transarterial chemoembolization prior to liver transplantation was performed in two incompletely ablated tumors.ResultsNo procedure-related major complications were recorded. During the waiting time to liver transplantation local tumor progression after ablation occurred in 3 nodules (25%). At histological examination of the explanted livers complete necrosis was found in 8 nodules (66.7%, all treated exclusively with laser ablation), partial necrosis >50% in 3 nodules (25%), and partial necrosis <50% in 1 nodule.ConclusionIn patients with cirrhotic livers awaiting liver transplantation, percutaneous laser ablation is safe and effective for the management of small hepatocellular carcinoma. |
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Keywords: | Hepatocellular carcinoma Liver transplantation Percutaneous laser ablation Tumor necrosis |
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