Effect of epidermal growth factor on non-steroidal anti-inflammatory drug-induced intestinal damage |
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Authors: | J F DiJoseph C L Wells |
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Institution: | (1) Division of Immunopharmacology, Wyeth-Ayerst Research, CN-8000, 08543-8000 Princeton, NJ, USA |
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Abstract: | Epidermal growth factor (EGF, 10 g/kg po, ip, or sc, BID, and 20 g/kg iv) had no protective activity in the indomethacin-induced intestinal lesion model (6 h model). In the ethanol-induced gastric lesion model, EGF (10 g/kg sc) reduced lesions by 52% and reduced gastric acid secretion by 68% (5 g/kg iv). In the 24 h indomethacin-induced intestinal lesion model, pretreatment with EGF (10 g/kg sc, BID; 1 day before and during indomethacin treatment) had no beneficial effects. Therefore, EGF had no protective effects against non-steroidal antiinflammatory drug (NSAID)-induced intestinal lesions at doses that protect against the necrotizing action of ethanol and that inhibit gastric acid secretion in the rat. |
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