纳米碳标记在结直肠癌根治术中的应用

目的探讨钠米碳淋巴结示踪剂在结直肠癌根治术中临床应用的意义。方法采用前瞻性病例对照研究，60例结直肠癌患者随机分为两组：30例患者于术前或术中先向癌灶周围注入钠米碳后再行根治术，30例对照组患者则不予注射纳米碳。分别记录检测黑染淋巴结与未黑染淋巴结数量及淋巴结转移情况。结果（1）钠米碳标记组平均每例清除12．6个淋巴结（6～18个），淋巴结黑染率为51．9％。对照组平均每例清除8．1个淋巴结（4～14个）。标记组淋巴结检出数明显高于对照组（P=0．0065）。（2）标记组黑染淋巴结癌肿侵犯阳性率33．6％，对照组淋巴结阳性率24．7％，标记组黑染淋巴结转移率高于对照组（P=0．014），同时标记组〈4mm转移淋巴结检出率高于对照组（P=0．0021）。（3）2例直肠癌患者术中发现肠系膜下动脉根部及髂内动脉旁有黑染淋巴结，并相应扩大手术切除范围，术后病理证实淋巴结有癌转移。结论钠米碳淋巴结示踪剂染色效果良好，术中易识别，能指导手术医师术中正确制定手术方案进行淋巴结清除。

Clinical application of carbon nanoparticles labeled lymph node in curative resection for colorectal carcinoma

Objective To explore the significance of clinical application of carbon nanoparticles labeled lymph node in curative resection for colorectal carcinoma.Methods With perspective research,60 patients with colorectal carcinoma were randomized into two groups:carbon nanoparticles were injected into the periphery of the tumor in 30 patients before or during the operation,and 30 patients were as control without any injection during operation.The number of lymph nodes(dyed or not dyed) and the location of metastat...