| HPLC法测定麻仁润肠丸中木香烃内酯和去氢木香内酯的含量 |
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| 引用本文： | 王瑞芬.HPLC法测定麻仁润肠丸中木香烃内酯和去氢木香内酯的含量[J].中国药事,2011,25(7):692-694. |
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| 作者姓名： | 王瑞芬 |
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| 作者单位： | 河南省濮阳市食品药品检验所,濮阳,457000 |
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| 摘 要： | 目的建立HPLC法测定麻仁润肠丸中木香烃内酯及去氢木香内酯的含量。方法采用Lanbo(Kromasil C18柱;流动相:甲醇-水(65∶35);流速:1.0mL.min-1;检测波长:225nm。结果木香烃内酯在0.2339~1.169μg范围内线性关系良好,r=0.9999,平均回收率为99.04%,RSD=0.43%(n=6);去氢木香内酯在0.1696~0.848μg范围内线性关系良好,r=0.9995,平均回收率为98.62%,RSD=0.49%(n=6)。结论该方法准确可靠、重复性好,可用于麻仁润肠丸的质量控制。
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| 关 键 词： | 麻仁润肠丸 高效液相色谱法 木香烃内酯 去氢木香内酯 |
Determination of Costunolide and Dehydrocostuslactone in Maren Runchang Pills by HPLC |
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| Wang Ruifen.Determination of Costunolide and Dehydrocostuslactone in Maren Runchang Pills by HPLC[J].Chinese Pharmaceutical Affairs,2011,25(7):692-694. |
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| Authors: | Wang Ruifen |
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| Institution: | Wang Ruifen(Puyang Institute for Food and Drug Control,Puyang 457000) |
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| Abstract: | Objective To establish a HPLC method to determine the content of Costunolide and Dehydrocostuslactone in Maren Runchang Pills.Methods Lanbo Kromasil C18 column was employed with the mobile phase of methanol-water（65∶35）.The flow rate was 1.0mL·min-1 and the detection wavelength was set at 225nm.Results The linear range of Costunolide fell within 0.2339～1.169μg（r=0.9999） and the average recovery rate was 99.04%（RSD=0.43%,n=6）.The linear range of Dehydrocostuslactone fell within 0.1696～0.848μg（r=0.9995） and the average recovery rate was 98.62%,（RSD=0.49%,n=6）.Conclusion The method is accurate with good reproducibility and strong specificity.It is suitable for the quality control of Maren Runchang Pills. |
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| Keywords: | Maren Runchang Pills HPLC costunolide dehydrocostuslactone |
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